Tamoxifen-induced regression of a choroidal metastasis in a man.

PDT in the fellow eye. In addition, angiography failed to demonstrate any abnormalities within the retinal circulation, which leads to the conclusion that there may be an increased sensitivity of the choroid in these patients. Four of the 8 patients were treated with combination PDT and intravitreal triamcinolone. It is unknown whether therapy combining PDT with intravitreal triamcinolone alters the response of the choroid because, to our knowledge, there have been no pathological studies of such eyes. Also unknown is the effect of the transient increase in intraocular pressure associated with intravitreal injections on the choroidal circulation in the presence of PDT; however, no patients developed evidence of prolonged pressure elevation. It must be noted that all patients in this series had minimally classic or occult membranes, and this may represent a risk factor in the development of choroidal infarcts following PDT. The importance of this article is that patients should be made aware of this rare complication, which includes the possibility of immediate and permanent loss of vision following PDT with verteporfin, especially in patients with purely occult or minimally classic lesions.